Serotonin and vasoconstrictor synergism

被引：69

作者：

Yildiz, O

Smith, JR

Purdy, RE ^{[1
]}

机构：

[1] Univ Calif Irvine, Coll Med, Dept Pharmacol, Irvine, CA 92697 USA

[2] Gulhane Sch med, Dept Med Pharmacol, TR-06018 Ankara, Turkey

来源：

LIFE SCIENCES | 1998年 / 62卷 / 19期

关键词：

serotonin; contraction; synergism;

D O I：

10.1016/S0024-3205(97)01166-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Contractile synergism between serotonin (5-hydroxytryptamine, 5-HT) and other vasoconstrictor substances has been observed in a number of peripheral and cerebrovascular blood vessels. This phenomenon may play an important role in certain pathological states such as hypertension, peripheral vascular disease, and coronary spasm. In the present review, we summarize studies on the synergism between serotonin and other vasoconstrictor agents and focus on a recently described type of vasoconstrictor synergism in which precontraction with a non-5-HT receptor agonist yields an enhanced contractile response to serotonin which is mediated by previously inactive or "silent" 5-HT receptor subtypes.

引用

收藏

页码：1723 / 1732

页数：10

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