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Osteoprotegerin ligand: a regulator of immune responses and bone physiology

被引：130
作者：
Kong, YY [1 ]
Boyle, WJ
Penninger, JM
机构：
[1] Pohang Univ Sci & Technol, Div Mol & Life Sci, Pohang 790784, South Korea
[2] Amgen Inc, Dept Cell Biol, Thousand Oaks, CA 91320 USA
[3] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2C1, Canada
[4] Univ Toronto, Dept Immunol, Toronto, ON M5G 2C1, Canada
来源：
IMMUNOLOGY TODAY | 2000年 / 21卷 / 10期
关键词：
D O I：
10.1016/S0167-5699(00)01718-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The TNF-family molecule osteoprotegerin ligand (OPGL, also known as TRANCE, RANKL and ODF) is a key regulator of bone remodeling and essential for the development and activation of osteoclasts. Intriguingly, OPGL also regulates T cell-dendritic cell communications, dendritic cell survival and lymph-node organogenesis. Here, Young-Yun Kong and colleagues discuss the role of OPGL, and its receptor RANK, in the immune system and in bone metabolism.
引用
收藏
页码：495 / 502
页数：8
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