Repeat sizes at CAG/CTG loci CTG18.1, ERDA1 and TGC13-7a in schizophrenia

被引：7

作者：

Bowen, T

Guy, CA

Cardno, AG

Vincent, JB

Kennedy, JL

Jones, LA

Gray, M

Sanders, RD

McCarthy, G

Murphy, KC

Owen, MJ

O'Donovan, MC

机构：

[1] Univ Wales Coll Cardiff, Coll Med, Div Psychol Med, Cardiff, S Glam, Wales

[2] Univ Wales Coll Cardiff, Coll Med, Div Med Genet, Cardiff, S Glam, Wales

[3] Univ Toronto, Ctr Addict & Mental Hlth, Neurogenet Sect, Clarke Div, Toronto, ON, Canada

来源：

PSYCHIATRIC GENETICS | 2000年 / 10卷 / 01期

关键词：

schizophrenia; trinucleotide repeats; CTG18.1; ERDA; 1; TGC13-7a;

D O I：

10.1097/00041444-200010010-00006

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A number of studies using the repeat expansion detection (RED) technique have suggested an association between unknown large CAG / CTG repeats and schizophrenia. The polymorphic CAG / CTG repeat loci CTG18.1 and ERDA1 have been reported to account for a high proportion (similar to 90%) of the large repeats detected by RED and may therefore be responsible for the cited association. The recently described locus TGC13-7a contains a highly polymorphic CTA/TAG and CAG / CTG composite repeat, and is thus another authentic candidate. In the present investigation, each locus was analysed for association with schizophrenia in a sample of 206 patients and 219 group-matched controls. No evidence for association of CTG18.1, ERDA1 and/or TGC13-7a with schizophrenia was found. The combined data accounted for only 54% of the CAG / CTG arrays of > 40 repeats found in our previous RED analysis. Psychiatr Genet 10:33-37 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：33 / 37

页数：5

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