Smoothened gene mutations found in digestive cancer have no aberrant Hedgehog signaling activity

被引:9
作者
Guleng, Bayasi
Tateishi, Keisuke
Ohta, Miki
Asaoka, Yoshinari
Jazag, Amarsanaa
Lin, Lian-Jie
Tanaka, Yasuo
Tada, Motohisa
Seto, Motoko
Kanai, Fumihiko
Kawabe, Takao
Omata, Masao
机构
[1] Univ Tokyo, Grad Sch Med, Dept Gastroenterol, Bunkyo Ku, Tokyo 1138655, Japan
[2] Univ Tokyo, Grad Sch Med, Dept Clin Drug Evaluat, Tokyo, Japan
[3] Tokyo Univ Hosp, Dept Endoscopy & Endoscop Surg, Tokyo 113, Japan
关键词
D O I
10.1007/s00535-006-1955-2
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
引用
收藏
页码:1238 / 1239
页数:3
相关论文
共 6 条
[1]   Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours [J].
Berman, DM ;
Karhadkar, SS ;
Maitra, A ;
de Oca, RM ;
Gerstenblith, MR ;
Briggs, K ;
Parker, AR ;
Shimada, Y ;
Eshleman, JR ;
Watkins, DN ;
Beachy, PA .
NATURE, 2003, 425 (6960) :846-851
[2]   p53-Independent negative regulation of p21/cyclin-dependent kinase-interacting protein 1 by the sonic hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma cells [J].
Ohta, M ;
Tateishi, K ;
Kanai, F ;
Watabe, H ;
Kondo, S ;
Guleng, B ;
Tanaka, Y ;
Asaoka, Y ;
Jazag, A ;
Imamura, J ;
Ijichi, H ;
Ikenoue, T ;
Sata, M ;
Miyagishi, M ;
Taira, K ;
Tada, M ;
Kawabe, T ;
Omata, M .
CANCER RESEARCH, 2005, 65 (23) :10822-10829
[3]  
Sasaki H, 1997, DEVELOPMENT, V124, P1313
[4]   Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine [J].
Taipale, J ;
Chen, JK ;
Cooper, MK ;
Wang, BL ;
Mann, RK ;
Milenkovic, L ;
Scott, MP ;
Beachy, PA .
NATURE, 2000, 406 (6799) :1005-1009
[5]   Activating Smoothened mutations in sporadic basal-cell carcinoma [J].
Xie, JW ;
Murone, M ;
Luoh, SM ;
Ryan, A ;
Gu, QM ;
Zhang, CH ;
Bonifas, JM ;
Lam, CW ;
Hynes, M ;
Goddard, A ;
Rosenthal, A ;
Epstein, EH ;
de Sauvage, FJ .
NATURE, 1998, 391 (6662) :90-92
[6]   Functional Smoothened is required for expression of GLI3 in colorectal carcinoma cells [J].
Zhu, YH ;
James, RM ;
Peter, A ;
Lomas, C ;
Cheung, F ;
Harrison, DJ ;
Bader, SA .
CANCER LETTERS, 2004, 207 (02) :205-214