Two 7α-hydroxylase enzymes in bile acid biosynthesis

被引：97

作者：

Schwarz, M ^{[1
]}

Lund, EG ^{[1
]}

Russell, DW ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Mol Genet, Dallas, TX 75235 USA

来源：

CURRENT OPINION IN LIPIDOLOGY | 1998年 / 9卷 / 02期

关键词：

D O I：

10.1097/00041433-199804000-00006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The addition of a 7-hydroxyl group is an early and often rate-limiting step in the synthesis of bile acids. This reaction is catalysed by two cytochrome P450 enzymes known as cholesterol 7 alpha-hydroxylase and oxysterol 7 alpha-hydroxylase. cDNAs encoding these proteins have been isolated and used to define two evolutionarily conserved pathways that produce 7 alpha-hydroxylated bile acids. (C) 1998 Rapid Science Ltd.

引用

页码：113 / 118

页数：6

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