Characterization of the novel allele HLA-B*4417: implications for bone marrow transplantation

被引：8

作者：

Elsner, HA

Schmitz, G

Ballas, M

Lenhard, V

Blasczyk, R

机构：

[1] Med Hsch Hannover, Abt Transfus Med, Dept Transfus Med, D-30625 Hannover, Germany

[2] Biotest AG, Dreieich, Germany

来源：

TISSUE ANTIGENS | 2000年 / 56卷 / 05期

关键词：

HLA-B*4417; bone marrow transplantation; sequence analysis;

D O I：

10.1034/j.1399-0039.2000.560513.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The identification of the novel allele HLA-B*4417, which was found in a blood donor of Caucasian origin, is described. In the sequence analysis the new allele differs from B*4402 by three nucleotides in exon 3. At the protein level, the new allele has two residue differences compared to B*4402. Due to substantial differences with other B*44 variants a possible mismatch may impair clinical outcome of bone marrow transplantation.

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收藏

页码：463 / 466

页数：4

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