Sweet dreams for LXR

被引：25

作者：

Lazar, Mitchell A. ^{[1
]}

Willson, Timothy M.

机构：

[1] Univ Penn, Sch Med, Inst Diabet Obes & Metab, Dept Med,Div Endocrinol Diabet & Metab, Philadelphia, PA 19104 USA

[2] GlaxoSmithKline Inc, Discovery Med Chem Mol Discovery Res, Res Triangle Pk, NC 27709 USA

来源：

CELL METABOLISM | 2007年 / 5卷 / 03期

关键词：

D O I：

10.1016/j.cmet.2007.02.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nuclear receptors (NRs) are transcription factors whose activities are modulated by the binding of small lipophilic ligands. The liver X receptors (LXRs) are an important pair of mammalian NRs that regulate lipid metabolism upon binding to cholesterol metabolites called oxysterols. A recent report that LXR activity is also regulated by binding to glucose (Mitro et al., 2007) expands the potential role of LXR in metabolic sensing and gene regulation. However, the hydrophilic nature of glucose and its low affinity for LXR present a challenge to central dogma about the nature of the NR-ligand interaction.

引用

页码：159 / 161

页数：3

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