Zebrafish: From disease modeling to drug discovery

被引：10

作者：

Rubinstein, AL ^{[1
]}

机构：

[1] Zygogen LLC, Atlanta, GA 30303 USA

来源：

CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT | 2003年 / 6卷 / 02期

关键词：

disease models; drug screening; target identification; target validation; zebrafish;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The study of zebrafish, a leading model organism for developmental biology, is rapidly expanding to include human disease. Zebrafish models based on known disease mechanisms have been developed in several therapeutic areas, including blood diseases, diabetes, muscular dystrophy, neurodegenerative disease, angiogenesis and lipid metabolism. This review summarizes recent progress in disease model development, and outlines the potential of zebrafish to contribute to drug discovery through the identification of novel drug targets, validation of those targets and screening for new therapeutic compounds.

引用

收藏

页码：218 / 223

页数：6

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