Discovering risperidone: the LSD model of psychopathology

被引：52

作者：

Colpaert, FC ^{[1
]}

机构：

[1] Ctr Rech Pierre Fabre, F-81106 Castres, France

来源：

NATURE REVIEWS DRUG DISCOVERY | 2003年 / 2卷 / 04期

关键词：

D O I：

10.1038/nrd1062

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In the 1970s and 1980s, Janssen Pharmaceutica Research, which had a broad interest in central nervous system disorders and nurtured intellectual freedom, developed original, and at times heretical, concepts. It took decades for the scientific community to endorse some of these concepts. Among them were such notions as an elementary particle of behaviour, the introduction of response quality in receptor theory, and the idea that tolerance does not develop to opiods. These concepts enabled the discovery of the antipsychotic risperidone, a unique full antagonist of the interoceptive effects of LSD.

引用

页码：315 / 320

页数：6

共 49 条

[1] Effects of the atypical antipsychotic risperidone on hostility and aggression in schizophrenia: a meta-analysis of controlled trials
Aleman, A
Kahn, RS
[J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2001, 11 (04) : 289 - 293
[2] ARIENS EJ, 1954, ARCH INT PHARMACOD T, V99, P32
[3] Bylund DB, 1996, PHARMACOL REV, V48, P353
[4] Colpaert F. C., 1982, DRUG DISCRIMINATION, P3
[5] Colpaert F. C., 1978, STIMULUS PROPERTIES, P301
[6] Large-amplitude 5-HT1A receptor activation:: a new mechanism of profound, central analgesia
Colpaert, FC
Tarayre, JP
Koek, W
Pauwels, PJ
Bardin, L
Xu, XJ
Wiesenfeld-Hallin, Z
Cosi, C
Carilla-Durand, E
Assié, MB
Vacher, B
[J]. NEUROPHARMACOLOGY, 2002, 43 (06) : 945 - 958
[7] Drug discrimination in neurobiology
Colpaert, FC
[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1999, 64 (02) : 337 - 345
[8] THEORETICAL AND METHODOLOGICAL CONSIDERATIONS ON DRUG DISCRIMINATION-LEARNING
COLPAERT, FC
NIEMEGEERS, CJE
JANSSEN, PAJ
[J]. PSYCHOPHARMACOLOGIA, 1976, 46 (02): : 169 - 177
[9] INVESTIGATIONS ON DRUG PRODUCED AND SUBJECTIVELY EXPERIENCED DISCRIMINATIVE STIMULI .1. FENTANYL CUE, A TOOL TO INVESTIGATE SUBJECTIVELY EXPERIENCED NARCOTIC DRUG ACTIONS
COLPAERT, FC
LAL, H
NIEMEGEERS, CJE
JANSSEN, PAJ
[J]. LIFE SCIENCES, 1975, 16 (05) : 705 - 715
[10] COLPAERT FC, 1976, J PHARMACOL EXP THER, V197, P180

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