Flavonoid derivatives as organometallic bioprobes

被引：20

作者：

Anson, CE

Creaser, CS

Malkov, AV

Mojovic, L

Stephenson, GR

机构：

[1] Nottingham Trent Univ, Sch Sci, Nottingham NG11 8NS, England

[2] Univ E Anglia, Sch Chem Sci & Pharm, Wolfson Mat & Catalysis Ctr, Norwich NR4 7TJ, Norfolk, England

[3] Nottingham Trent Univ, Interdisciplinary Biomed Res Ctr, Nottingham NG11 8NS, England

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2003年 / 668卷 / 1-2期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

flavonoids; root nodulation; rhizobium; gene induction; signal molecules; organometalcarbonyl groups; tricarbonyliron; synthesis; bioprobes;

D O I：

10.1016/S0022-328X(02)02146-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis of organoiron derivatives of biologically active flavonoids is described. Lithium enolates of functionalised protected acetophenones and metallated derivatives of substituted aromatic rings have been employed as nucleophiles in combination with tricarbonyl(eta(5)-cyclohexadienyl)iron electrophiles. Products have been converted into flavonoid and chalcone derivatives. Enolates generated from protected flavanones have also been used in nucleophile addition reactions, and a one-pot in situ protection, nucleophile addition, deprotection sequence is reported. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：101 / 122

页数：22

共 96 条

[1]

AHMAD M, 1991, J CHEM RES MINIPRINT, V5, P901

[2] BIOMIMETIC APPROACH TO BIFLAVONOIDS - OXIDATIVE COUPLING OF 2'-HYDROXYCHALCONES WITH I2 IN ALKALINE METHANOL [J].