Decreased myocardial 123I-MIBG uptake in Parkinson's disease

被引：46

作者：

Iwasa, K

Nakajima, K

Yoshikawa, H

Tada, A

Taki, J

Takamori, M

机构：

[1] Kanazawa Univ, Sch Med, Dept Neurol, Kanazawa, Ishikawa 920, Japan

[2] Kanazawa Univ, Sch Med, Dept Nucl Med, Kanazawa, Ishikawa 920, Japan

[3] Kanazawa Natl Hosp, Dept Neurol, Kanazawa, Ishikawa, Japan

[4] Kanazawa Natl Hosp, Dept Radiol, Kanazawa, Ishikawa, Japan

来源：

ACTA NEUROLOGICA SCANDINAVICA | 1998年 / 97卷 / 05期

关键词：

I-123-metaiodobenzylguanidine (MIBG); Parkinson's disease; transporter;

D O I：

10.1111/j.1600-0404.1998.tb05957.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied myocardial I-123-metaiodobenzylguanidine (MIBG) accumulation in 12 patients with Parkinson's disease (PD). MIBG is an analog of norepinephrine (NE) and a tracer for sympathetic neuron integrity and function. MIBG uptake of the myocardium was significantly lower in PD than in controls. The heart to mediastinum ratio (H/M) was calculated by using the average count per pixel for the heart and mediastinum. In PD, H/M was lower than in controls (P<0.0001), while the washout ratio of the heart was higher (P<0.001). A decrease in myocardial accumulation of MIBG was observed in the early stage of PD, This suggests that the measurement of MIBG may help the diagnosis of early PD, and the causative factor underlying in PD may be operating the NE neuron as well as dopamine neuron.

引用

页码：303 / 306

页数：4

共 19 条

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