Familial aggregation for conduct disorder symptomatology: the role of genes, marital discord and family adaptability

被引:51
作者
Meyer, JM
Rutter, M
Silberg, JL
Maes, HH
Simonoff, E
Shillady, LL
Pickles, A
Hewitt, JK
Eaves, LJ
机构
[1] Virginia Commonwealth Univ, Med Coll Virginia, Virginia Inst Psychiat & Behav Genet, Richmond, VA USA
[2] Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA
[3] Millennium Pharmaceut Inc, Cambridge, MA USA
[4] Guys & St Thomas Hosp, Sch Med, MRC, Child Psychiat Unit, London SE1 9RT, England
[5] Guys & St Thomas Hosp, Sch Med, Social Genet & Dev Psychiat Res Ctr, Inst Psychiat, London SE1 9RT, England
[6] Guys & St Thomas Hosp, Sch Med, Dept Child & Adolescent Psychiat & Psychol, London SE1 9RT, England
[7] Univ Manchester, Dept Med, Sch Epidemiol & Hlth Sci, Manchester M13 9PL, Lancs, England
关键词
D O I
10.1017/S0033291799002408
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Background. There is extensive evidence of statistical associations between family discord/maladaptation and antisocial behaviour in the children, but questions re:main on the extent to which the psychopathological risks are genetically or environmentally mediated. Methods. Twin pairs (N = 1350), aged 8 to 16 years, in the general population-based Virginia Twin Study of Adolescent Behavioral Development were assessed using the Child and Adolescent Psychiatric Assessment interview administered separately to both twins and both parents. Structured interviews for parental lifetime psychiatric disorders were also administered to the mothers and fathers. Maternal reports on Olsson's Family Adaptability and Cohesiveness questionnaire and the Dyadic Adjustment Scale were used as indices of the family environment. A path analytical model based on an extended twin-family design was used to test hypotheses about parent-offspring similarity for conduct disorder symptomatology. Results. Family discord and maladaptation, which intercorrelated at 0.63, were associated with a roughly two-fold increase in risk for conduct disorder symptomatology. When parental conduct disorder was included in the model the environmental mediation effect for family maladaptation remained, but that for family discord was lost. Conclusion. It is concluded that there is true environmental mediation from family maladaptation, operating as a shared effect, which accounts for 3.5 % of the phenotypic variance. The assumptions underlying this genetic research strategy are made explicit, together with its strengths and limitations.
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页码:759 / 774
页数:16
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