Early formation of mRNP: License for export or quality control?

被引：101

作者：

Jensen, TH

Dower, K

Libri, D

Rosbash, M

机构：

[1] Aarhus Univ, Dept Mol Biol, DK-8000 Aarhus C, Denmark

[2] Brandeis Univ, Howard Hughes Med Inst, Dept Biol, Waltham, MA 02454 USA

[3] CNRS, Ctr Genet Mol, F-91190 Gif Sur Yvette, Paris, France

来源：

MOLECULAR CELL | 2003年 / 11卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1097-2765(03)00191-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eukaryotic mRNA is processed by enzymes and packaged with proteins within nuclei to generate functional messenger ribonucleoprotein (mRNP) particles. Processing and packaging factors can interact with mRNA cotranscriptionally to form an early mRNP. Erroneous mRNP formation leads to nuclear retention and degradation of the mRNA. It therefore appears that one function of cotranscriptional mRNP assembly is to discard aberrant mRNPs early in their blogenesis. Cotranscriptional mRNP assembly may also enable the transcription machinery to respond to improper mRNP formation.

引用

页码：1129 / 1138

页数：10

共 105 条

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