Foamy virus vectors

被引：141

作者：

Russell, DW

Miller, AD

机构：

[1] FRED HUTCHINSON CANC RES CTR,SEATTLE,WA 98104

[2] UNIV WASHINGTON,DIV HEMATOL,SEATTLE,WA 98195

[3] UNIV WASHINGTON,DEPT PATHOL,SEATTLE,WA 98195

来源：

JOURNAL OF VIROLOGY | 1996年 / 70卷 / 01期

关键词：

D O I：

10.1128/JVI.70.1.217-222.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human foamy virus (HFV) is a retrovirus of the spumavirus family, We have constructed vectors based on HFV that encode neomycin phosphotransferase and alkaline phosphatase. These vectors are able to transduce a wide variety of vertebrate cells by integration of the vector genome, Unlike vectors based on murine leukemia virus, HFV vectors are not inactivated by human serum, and they transduce stationary-phase cultures more efficiently than murine leukemia virus vectors. These properties, as well as their large packaging capacity, make HFV vectors promising gene transfer vehicles.

引用

页码：217 / 222

页数：6

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