PAK as a therapeutic target in gastric cancer

被引：37

作者：

Li, Xiaodong

Liu, Funan

Li, Feng ^{[1
]}

机构：

[1] China Med Univ, Dept Cell Biol, Key Lab Cell Biol, Minist Publ Hlth, Shenyang 110001, Liaoning, Peoples R China

来源：

EXPERT OPINION ON THERAPEUTIC TARGETS | 2010年 / 14卷 / 04期

基金：

中国国家自然科学基金;

关键词：

P21-ACTIVATED KINASE PAK1; LIGHT-CHAIN KINASE; RHO-FAMILY; CYCLIN D1; COLORECTAL-CANCER; GENE-EXPRESSION; EXCHANGE FACTOR; DOWN-REGULATION; ARP2/3; COMPLEX; CELL-MIGRATION;

D O I：

10.1517/14728221003642019

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Areas covered in this review: The complex regulation of PAKs through their upstream or downstream effectors in human cancers, especially in gastric cancer, are described and the identified inhibitors of PAKs are summarized. What the readers will gain: The structural differences and activation mechanisms between two subgroups of PAK are described. Both groups of PAKs play complicated and important roles in human gastric cancer, which indicated a possible way for us to identify the specific inhibitors targeting PAKs for gastric cancer. Take home message: PAKs play important roles in progression of many cancer types, the full mechanisms of PAKs in gastric cancer are still unclear. It seems there are different roles for two groups of PAKs in cancers. Group I PAKs play their functions mostly through their specific substrates, however, many binding partners that are independent of phosphorylation by group II PAKs were identified. Finding specific inhibitors of PAKs will help us discover the roles of PAKs and target these kinases in human gastric cancer.

引用

页码：419 / 433

页数：15

共 135 条

[1]

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia [J].