Growth hormone signalling mechanisms: Involvement of the tyrosine kinase JAK2

被引：33

作者：

Argetsinger, LS

CarterSu, C

机构：

[1] Department of Physiology, University of Michigan Medical School, Ann Arbor, MI

来源：

HORMONE RESEARCH | 1996年 / 45卷

关键词：

growth hormone; insulin receptor substrate-1; JAK2; MAP kinase; STAT;

D O I：

10.1159/000184823

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Demonstration that the tyrosine kinase JAK2 is activated in response to growth hormone (GH) has established tyrosyl phosphorylation as a signalling mechanism for GH, In addition a number of signalling molecules have recently been identified that interact with the GH receptor/JAK2 complex and require JAK2 for activation. These pathways regulate cellular functions including gene transcription, metabolite transport, and metabolism and contribute to the ability of GH to control body growth and metabolism.

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页码：22 / 24

页数：3

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