Recombinant immunotoxins

被引：18

作者：

Pastan, I

Pai, LH

Brinkmann, U

FitzGerald, D

机构：

来源：

BREAST CANCER RESEARCH AND TREATMENT | 1996年 / 38卷 / 01期

关键词：

breast cancer; cancer treatment; colon cancer; Pseudomonas exotoxin; EPIDERMAL GROWTH-FACTOR; PSEUDOMONAS EXOTOXIN-A; MONOCLONAL-ANTIBODY; FACTOR RECEPTOR; COLON-CANCER; CARCINOMA; CELLS; MICE; EXPRESSION; PROTEINS;

D O I：

10.1007/BF01803778

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pseudomonas exotoxin has been genetically modified so that it targets cancer cells. This was accomplished by deleting its cell binding domain and replacing it with Fv fragments of antibodies that react with breast, colon, and other cancers. Several recombinant immunotoxins are now in clinical trials.

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页码：3 / 9

页数：7

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