A base-catalyzed domino-isomerization-hydroamination reaction - A new synthetic route to amphetamines

被引：69

作者：

Hartung, CG

Breindl, C

Tillack, A

Beller, M

机构：

[1] Univ Rostock eV, IfOK, D-18055 Rostock, Germany

[2] Tech Univ Munich, Inst Anorgan Chem, D-85747 Garching, Germany

来源：

TETRAHEDRON | 2000年 / 56卷 / 29期

关键词：

domino-isomerization-amination reaction; base-catalysis; hydroamination; amphetamines;

D O I：

10.1016/S0040-4020(00)00436-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of pharmaceutically interesting amphetamines by a base-catalyzed domino-isomerization-hydroamination reaction is presented. Starting from allylbenzene and various primary or secondary amines, the basic structural pattern of amphetamines is synthesized directly in yields of up to 91% in the presence of catalytic amounts of n-butyllithium. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：5157 / 5162

页数：6

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