A new convenient synthesis of 5-acyl-1,2,3,4-tetrahydropyrimidine-2-thiones/ones

被引：113

作者：

Shutalev, AD ^{[1
]}

Kishko, EA ^{[1
]}

Sivova, NV ^{[1
]}

Kuznetsov, AY ^{[1
]}

机构：

[1] State Acad Fine Chem Technol, Dept Organ Chem, Moscow 117571, Russia

来源：

MOLECULES | 1998年 / 3卷 / 03期

关键词：

alpha-tosyl substituted (thio)ureas; 5-acyl-1,2,3,4-tetrahydropyrimidine-2-thiones/ones;

D O I：

10.3390/30300100

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An efficient one-pot synthesis of 5-acyl-1,2,3,4-tetrahydropyrimidine-2-thiones/ones is described. The synthesis is based on the reaction of readily available a-tosyl substituted thioureas or ureas with enolates of beta-oxoesters or 1,3-dicarbonyl compounds followed by acid-catalyzed dehydration of the obtained 5-acyl-4-hydroxyhexahydropyrimidine-2-thiones/ones.

引用

页码：100 / 106

页数：7

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