Modifications of the 4,4′-residues and SAR studies of biphalin, a highly potent opioid receptor active peptide

被引：25

作者：

Li, GG

Haq, W

Xiang, L

Lou, BS

Hughes, R

De Leon, IA

Davis, P

Gillespie, TJ

Romanowski, M

Zhu, XY

Misicka, A

Lipkowski, AW

Porreca, F

Davis, TP

Yamamura, HI

O'Brien, DF

Hruby, VJ ^{[1
]}

机构：

[1] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA

[2] Univ Arizona, Dept Pharmacol, Tucson, AZ 85721 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(98)00065-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Modifications of 4,4' residues of Biphalin have resulted in greater binding selectivity and biological potency for the mu opioid receptor. A higher partition coefficient across the phospholipid bilayer membrane has been achieved by using a beta-branched unusual amino acids. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：555 / 560

页数：6

共 26 条

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