Levetiracetam for the treatment of neonatal seizures

被引：54

作者：

Shoemaker, Michael T.

Rotenberg, Joshua S.

机构：

[1] Wilford Hall USAF Med Ctr, Dept Pediat Neurol, Lackland AFB, TX 78236 USA

[2] Wilford Hall USAF Med Ctr, Dept Neonatol, Lackland AFB, TX 78236 USA

来源：

JOURNAL OF CHILD NEUROLOGY | 2007年 / 22卷 / 01期

关键词：

levitiracetam; neonate; seizure;

D O I：

10.1177/0883073807299973

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Seizures are a common occurrence in the neonatal intensive care unit, especially among low-birth-weight infants. The efficacy and safety of standard anticonvulsants have not been evaluated extensively in the neonate. In addition, there is concern for the adverse effects of phenobarbital on longterm development. Levetiracetam has been a commonly prescribed oral anticonvulsant for the use of adjunctive therapy for partial seizures in adults with favorable tolerability, and it has been recently approved for children older than age 4 years. There are no published studies regarding the safety and efficacy of this medication in the infant population. This report describes the initiation of levetiracetam in 3 infants, aged 2 days to 3 months, for refractory seizures or intolerance to other anticonvulsants. Each patient was without seizure on levetiracetam monotherapy, and there were no adverse effects.

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页码：95 / 98

页数：4

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