Recent advances in α1-adrenoceptor pharmacology

被引：78

作者：

Koshimizu, T ^{[1
]}

Tanoue, A ^{[1
]}

Hirasawa, A ^{[1
]}

Yamauchi, J ^{[1
]}

Tsujimoto, G ^{[1
]}

机构：

[1] Natl Res Inst Child Hlth & Dev, Dept Mol Cell Pharmacol, Setagaya Ku, Tokyo 154, Japan

来源：

PHARMACOLOGY & THERAPEUTICS | 2003年 / 98卷 / 02期

基金：

日本科学技术振兴机构;

关键词：

alpha(1)-adrenergic receptors; cellular signaling; cellular localization; transgenic mouse; knockout mouse; pharmacogenomics;

D O I：

10.1016/S0163-7258(03)00033-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

alpha(1)-Adrenergic receptors (ARs) mediate some of the main actions of the natural catecholamines, adrenaline and noradrenaline. They participate in many essential physiological processes, such as sympathetic neurotransmission, modulation of hepatic metabolism, control of vascular tone, cardiac contraction, and the regulation of smooth muscle activity in the genitourinary system. Here, we review recent progress on subtype-specific subcellular localization, participation in signaling cascades, and the pivotal function of alpha(1)-ARs, as delineated through studies on genetically engineered animals. Together, these findings will provide new insights into the physiological and pathophysiological roles of the alpha(1)-ARs. (C) 2003 Elsevier Science Inc. All rights reserved.

引用

页码：235 / 244

页数：10

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