Central role for the lens in cave fish eye degeneration

被引：199

作者：

Yamamoto, Y ^{[1
]}

Jeffery, WR ^{[1
]}

机构：

[1] Univ Maryland, Dept Biol, College Pk, MD 20742 USA

来源：

SCIENCE | 2000年 / 289卷 / 5479期

关键词：

D O I：

10.1126/science.289.5479.631

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Astyanax mexicanus is a teleost with eyed surface-dwelling and eyeless cave-dwelling forms. Eye formation is initiated in cave fish embryos, but the eye subsequently arrests and degenerates. The surface fish lens stimulates growth and development after transplantation into the cave fish optic cup, restoring optic tissues lost during cave fish evolution. Conversely, eye growth and development are retarded following transplantation of a surface fish lens into a cave fish optic cup or lens extirpation. These results show that evolutionary changes in an inductive signal from the Lens are involved in cave fish eye degeneration.

引用

页码：631 / 633

页数：3

共 15 条

[1]

AVISE JC, 1972, EVOLUTION, V26, P1, DOI 10.1111/j.1558-5646.1972.tb00170.x

[2]

CAHN PH, 1958, B AM MUS NAT HIST, V115, P75

[3] IDENTIFICATION OF PROGRAMMED CELL-DEATH INSITU VIA SPECIFIC LABELING OF NUCLEAR-DNA FRAGMENTATION [J].