Telomere biology: A new player in the end zone

被引:25
作者
Colgin, L [1 ]
Reddel, R [1 ]
机构
[1] Childrens Med Res Inst, Canc Res Unit, Westmead, NSW 2145, Australia
关键词
D O I
10.1016/j.cub.2004.09.075
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Yet another protein has been added to the crowd of players found at the ends of chromosomes. Known variously as PTOP, PIP1 or TINT1, this negative regulator of telomere length connects some of the key proteins already known to be present - TRF1, TIN2, POT1, and TRF2 - and adds even more complexity to telomere protein interactions.
引用
收藏
页码:R901 / R902
页数:2
相关论文
共 13 条
[1]   Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1 [J].
Armbruster, BN ;
Linardic, CM ;
Veldman, T ;
Bansal, NP ;
Downie, DL ;
Counter, CM .
MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (08) :3552-3561
[2]   Human POT1 facilitates telomere elongation by telomerase [J].
Colgin, LM ;
Baran, K ;
Baumann, P ;
Cech, TR ;
Reddel, RR .
CURRENT BIOLOGY, 2003, 13 (11) :942-946
[3]   Resolution of sister telomere association is required for progression through mitosis [J].
Dynek, JN ;
Smith, S .
SCIENCE, 2004, 304 (5667) :97-100
[4]   A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2 [J].
Houghtaling, BR ;
Cuttonaro, L ;
Chang, W ;
Smith, S .
CURRENT BIOLOGY, 2004, 14 (18) :1621-1631
[5]   TIN2, a new regulator of telomere length in human cells [J].
Kim, SH ;
Kaminker, P ;
Campisi, J .
NATURE GENETICS, 1999, 23 (04) :405-412
[6]  
KIM SH, 2004, IN PRESS J BIOL CHEM
[7]   PTOP interacts with POT1 and regulates its localization to telomeres [J].
Liu, D ;
Safari, A ;
O'Connor, MS ;
Chan, DW ;
Laegeler, A ;
Qin, J ;
Zhou, SY .
NATURE CELL BIOLOGY, 2004, 6 (07) :673-680
[8]   POT1 as a terminal transducer of TRF1 telomere length control [J].
Loayza, D ;
de Lange, T .
NATURE, 2003, 423 (6943) :1013-1018
[9]   Regulation of telomerase by telomeric proteins [J].
Smogorzewska, A ;
de Lange, T .
ANNUAL REVIEW OF BIOCHEMISTRY, 2004, 73 :177-208
[10]   Control of human telomere length by TRF1 and TRF2 [J].
Smogorzewska, A ;
Van Steensel, B ;
Bianchi, A ;
Oelmann, S ;
Schaefer, MR ;
Schnapp, G ;
De Lange, T .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (05) :1659-1668