Chromosome ends: all the same under their caps

被引：146

作者：

Pryde, FE ^{[1
]}

Gorham, HC ^{[1
]}

Louis, EJ ^{[1
]}

机构：

[1] John Radcliffe Hosp, Inst Mol Med, Oxford OX3 9DS, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1997年 / 7卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0959-437X(97)80046-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The recent characterisation of subtelomeric regions from a variety of organisms from yeast to man has led to the realisation that all chromosome ends are similar in structure although maintenance of the terminus varies. The mosaic of repeats and proteins associated with telomeres has an architectural role which divides the genome into two domains, allowing for the adaptive use of the region as well as the evolution of non-telomerase-mediated telomere maintenance. (C) Current Biology Ltd ISSN 0959-437X.

引用

页码：822 / 828

页数：7

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