Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase

被引：93

作者：

Ducker, CE ^{[1
]}

Stettler, EM ^{[1
]}

French, KJ ^{[1
]}

Upson, JJ ^{[1
]}

Smith, CD ^{[1
]}

机构：

[1] Penn State Univ, Dept Pharmacol, Coll Med, Hershey, PA 17033 USA

来源：

ONCOGENE | 2004年 / 23卷 / 57期

关键词：

palmitoylation; protein; palmitoyl acyltransferase; RAS; intracellular signaling;

D O I：

10.1038/sj.onc.1208171

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein palmitoyltransferases (PATs) represent an exciting new target for anticancer drug design due to their pivotal roles in the subcellular localization of a number of oncogenes. We show that the Huntingtin interacting protein 14 (HIP14) is a PAT with a preference for the farnesyl-dependent palmitoylation motif found in H- and N-RAS. Characterization of HIP14 in mouse cells has revealed that it has the ability to induce colony formation in cell culture, anchorage-independent growth, and tumors in mice. Activity of the enzyme and its ability to transform cells is dependent on critical residues in the active site of the enzyme.

引用

页码：9230 / 9237

页数：8

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