Increase of PTEN gene expression in insulin resistance

被引：52

作者：

Lo, YT

Tsao, CJ

Liu, IM

Liou, SS

Cheng, JT ^{[1
]}

机构：

[1] Natl Cheng Kung Univ, Coll Med, Dept Pharmacol, Tainan, Taiwan

[2] Tajen Inst Technol, Dept Pharm, Ping Tung Shien, Taiwan

[3] Natl Cheng Kung Univ, Coll Med, Dept Internal Med, Tainan 70101, Taiwan

[4] Chungtai Inst Hlth Sci & Technol, Dept Hosp & Hlth Care Adm, Taichung, Taiwan

来源：

HORMONE AND METABOLIC RESEARCH | 2004年 / 36卷 / 10期

关键词：

glucose-insulin index; insulin resistance; PTEN; Zucker rats;

D O I：

10.1055/s-2004-826016

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Phosphatase and tensin homologue deleted from chromosome ten (PTEN) has recently been characterized as a regulator of insulin sensitivity in the insulin target tissue. However, whether PTEN gene expression is changed in insulin resistance remains unclear. We observed that both the mRNA and protein level of PTEN in soleus muscle isolated from the obese Zucker rats (fa/ fa) were increased compared to the age-matched lean group. Similarly, both the mRNA and protein level of PTEN in soleus muscle of the fructose-fed lean Zucker rats (Fa/Fa) showing the higher glucose-insulin index were higher than that of the regular chow fed group. These results suggest that increase of PTEN gene expression seems to be related to the development of insulin resistance.ed compared to the age-matched lean group.

引用

收藏

页码：662 / 666

页数：5

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