A prospective study on factors influencing aspergillus spore load in the air during renovation works in a neonatal intensive care unit

被引:64
作者
Mahieu, LM
De Dooy, JJ
Van Laer, FA
Jansens, H
Ieven, MM
机构
[1] Univ Antwerp Hosp, Dept Paediat, Div Neonatol, B-2650 Edegem, Belgium
[2] Univ Antwerp Hosp, Dept Hosp Hyg, B-2650 Edegem, Belgium
[3] Univ Antwerp Hosp, Dept Clin Microbiol, B-2650 Edegem, Belgium
关键词
Aspergillus; renovation works; air sampling; air filtration; meteorological factors; nasopharyngeal colonization; neonates;
D O I
10.1053/jhin.2000.0773
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The relationship between air contamination (cfu/m(3)) with fungal spores, especially Aspergillus spp., in three renovation areas of a neonatal intensive care unit (NICU) and colonization and infection rates in a high care area (HC) equipped with high efficiency particulate air (HEPA) filtration and a high pressure system, was evaluated. Data on the type and site of renovation works, outdoor meteorological conditions, patient crowding and nasopharyngeal colonization rate were collected. Factors not associated with Aspergillus spp. concentration were outdoor temperature, air pressure, wind speed, humidity, rainfall, patient density in the NICU, renovation works in the administrative area and in the isolation rooms. Multivariate analysis revealed that rt novation works and air concentration of Aspergillus spp. spores in the medium care area (MC) resulted in a significant increase of the concentration in the HC of the NICU. The use of a mobile HEPA air filtration system (MedicCleanAir(R)Forte, Willebroek, Belgium) caused a significant decrease in the Aspergillus spp. concentration. There was no relationship between Aspergillus spp. air concentration and nasopharyngeal colonization in the neonates. Invasive aspergillosis did not occur during the renovation. This study highlights the importance of optimal physical barriers and air filtration to decrease airborne fungal spores in high-risk units during renovation works. The value of patient surveillance and environmental air sampling is questionable since no relationship was found between air contamination and colonization in patients. (C) 2000 The Hospital Infection Society.
引用
收藏
页码:191 / 197
页数:7
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