The STR/ort mouse model of spontaneous osteoarthritis - an update

被引：44

作者：

Staines, K. A. ^{[1
,2
,3
]}

Poulet, B. ^{[4
]}

Wentworth, D. N. ^{[5
]}

Pitsillides, A. A. ^{[5
]}

机构：

[1] Univ Edinburgh, Roslin Inst, Easter Bush EH25 9RG, Midlothian, Scotland

[2] Univ Edinburgh, RDSVS, Easter Bush EH25 9RG, Midlothian, Scotland

[3] Edinburgh Napier Univ, Sch Appl Sci, Sighthill Campus, Edinburgh EH11 4BN, Midlothian, Scotland

[4] Univ Liverpool, Inst Ageing & Chron Dis, Musculoskeletal Biol 1, Room 286,Second Floor,William Henry Duncan Bldg, Liverpool L7 8TX, Merseyside, England

[5] Royal Vet Coll, Royal Coll St, London NW1 0TU, England

来源：

OSTEOARTHRITIS AND CARTILAGE | 2017年 / 25卷 / 06期

关键词：

STR/ort; Osteoarthritis; Articular cartilage; Subchondral bone; DEGENERATIVE JOINT DISEASE; ARTICULAR-CARTILAGE PROTEOGLYCANS; KNEE-JOINT; CHONDROCYTE DEATH; SUBCHONDRAL BONE; MICE; EXPRESSION; COLLAGEN; PROGRESSION; DAMAGE;

D O I：

10.1016/j.joca.2016.12.014

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

Osteoarthritis is a degenerative joint disease and a world-wide healthcare burden. Characterized by cartilage degradation, subchondral bone thickening and osteophyte formation, osteoarthritis inflicts much pain and suffering, for which there are currently no disease-modifying treatments available. Mouse models of osteoarthritis are proving critical in advancing our understanding of the underpinning molecular mechanisms. The STR/ort mouse is a well-recognized model which develops a natural form of osteoarthritis very similar to the human disease. In this Review we discuss the use of the STR/ort mouse in understanding this multifactorial disease with an emphasis on recent advances in its genetics and its bone, endochondral and immune phenotypes. (C) 2016 The Authors. Published by Elsevier Ltd

引用

页码：802 / 808

页数：7

共 84 条

[1]

A METABOLIC DYSFUNCTION IN EARLY MURINE OSTEO-ARTHRITIS [J].

ALTMAN, FP .

ANNALS OF THE RHEUMATIC DISEASES, 1981, 40 (03) :303-306

[2]

ENZYME HISTOCHEMICAL-CHANGES IN MURINE OSTEOARTHRITIS [J].

ALTMAN, FP .

HISTOCHEMISTRY, 1982, 74 (01) :43-48

[3]

Collagen remodeling in the anterior cruciate ligament associated with developing spontaneous murine osteoarthritis [J].

Anderson-MacKenzie, JM ;

Billingham, ME ;

Bailey, AJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 258 (03) :763-767

[4]

Sclerostin Is a Locally Acting Regulator of Late-Osteoblast/Preosteocyte Differentiation and Regulates Mineralization Through a MEPE-ASARM-Dependent Mechanism [J].

Atkins, Gerald J. ;

Rowe, Peter S. ;

Lim, Hui P. ;

Welldon, Katie J. ;

Ormsby, Renee ;

Wijenayaka, Asiri R. ;

Zelenchuk, Lesya ;

Evdokiou, Andreas ;

Findlay, David M. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2011, 26 (07) :1425-1436

[5]

Averbeck B, 2004, J RHEUMATOL, V31, P2013

[6]

SUBCHONDRAL BONE-FORMATION IN ARTHROSIS - POLYCHROME LABELING STUDIES IN MICE [J].

BENSKE, J ;

SCHUNKE, M ;

TILLMANN, B .

ACTA ORTHOPAEDICA SCANDINAVICA, 1988, 59 (05) :536-541

[7]

Brewster M, 1998, ARTHRITIS RHEUM, V41, P1639, DOI 10.1002/1529-0131(199809)41:9<1639::AID-ART15>3.0.CO

[8]

2-0

[9]

Chondrocyte cytokine and growth factor expression in murine osteoarthritis [J].

Chambers, MG ;

Bayliss, MT ;

Mason, RM .

OSTEOARTHRITIS AND CARTILAGE, 1997, 5 (05) :301-308

[10]

Expression of collagen and aggrecan genes in normal and osteoarthritic murine knee joints [J].

Chambers, MG ;

Kuffner, T ;

Cowan, SK ;

Cheah, KSE ;

Mason, RM .

OSTEOARTHRITIS AND CARTILAGE, 2002, 10 (01) :51-61

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