Regulatory evolution across the protein interaction network

被引：55

作者：

Lemos, B ^{[1
]}

Meiklejohn, CD ^{[1
]}

Hartl, DL ^{[1
]}

机构：

[1] Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA

来源：

NATURE GENETICS | 2004年 / 36卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/ng1427

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Protein-protein interactions may impose constraints on both structural and regulatory evolution. Here we show that protein-protein interactions are negatively associated with evolutionary variation in gene expression. Moreover, interacting proteins have similar levels of variation in expression, and their expression levels are positively correlated across strains. Our results suggest that interacting proteins undergo similar evolutionary dynamics, and that their expression levels are evolutionarily coupled. These patterns hold for organisms as diverse as budding yeast and fruit flies.

引用

页码：1059 / 1060

页数：2

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