Impact of African herbal medicines on antiretroviral metabolism

被引：79

作者：

Mills, E ^{[1
]}

Foster, BC

van Heeswijk, R

Phillips, E

Wilson, K

Leonard, B

Kosuge, K

Kanfer, I

机构：

[1] McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON, Canada

[2] Univ British Columbia, Ctr Excellence HIV AIDS, Vancouver, BC V5Z 1M9, Canada

[3] Ottawa Gen Hosp, Div Infect Dis, Ottawa, ON K1H 8L6, Canada

[4] Univ Toronto, Dept Med, Toronto, ON, Canada

[5] Canadian Coll Naturopath Med, Toronto, ON, Canada

[6] Rhodes Univ, Fac Pharm, ZA-6140 Grahamstown, South Africa

来源：

AIDS | 2005年 / 19卷 / 01期

关键词：

D O I：

10.1097/00002030-200501030-00013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We examined the effects of two African herbal medicines recommended for HIV/AIDS patients on. antiretroviral metabolism. Extracts from Hypoxis and Sutherlandia showed significant effects on cytochrome P450 3A4 metabolism and activated the pregnane X receptor approximately twofold. P-glycoprotein expression was inhibited, with Hypoxis showing 42-51% and Sutherlandia showing 19-31% of activity compared with verapamil. Initiating policies to provide herbal medicines with antiretroviral agents may put patients at risk of treatment failure, viral resistance or drug toxicity.

引用

页码：95 / 97

页数：3