Fortuitous convergences: the beginnings of JUN

被引：113

作者：

Vogt, PK ^{[1
]}

机构：

[1] Scripps Res Inst, Div Oncovirol, La Jolla, CA 92037 USA

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 06期

关键词：

D O I：

10.1038/nrc818

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The oncogenic cellular phenotype reflects transcriptional and post-transcriptional changes in gene expression. The popular technique of expression profiling with microarrays highlights that changes in messenger RNA levels are important determinants of oncogenicity. The idea that upregulation and downregulation of specific crucial target genes can cause cancer derives from the discovery of oncogenic transcription factors. So, how was JUN - the first oncogenic transcription factor - discovered?.

引用

页码：465 / 469

页数：5

共 68 条

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