The molecular basis of the host response to lipopolysaccharide

被引：305

作者：

Bryant, Clare E. ^{[1
]}

Spring, David R. ^{[2
]}

Gangloff, Monique ^{[3
]}

Gay, Nicholas J. ^{[3
]}

机构：

[1] Univ Cambridge, Dept Vet Med, Cambridge CB3 OES, England

[2] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[3] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

来源：

NATURE REVIEWS MICROBIOLOGY | 2010年 / 8卷 / 01期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

LIPID-A; ENDOTOXIN ANTAGONIST; CRYSTAL-STRUCTURE; ADAPTER MOLECULE; STRUCTURAL BASIS; RECEPTOR FAMILY; TOLL; TLR4; LPS; MD-2;

D O I：

10.1038/nrmicro2266

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Lipopolysaccharide (LPS), which is produced by Gram-negative bacteria, is a powerful activator of innate immune responses. LPS binds to the proteins Toll-like receptor 4 (TLR4) and MD2 to activate pro-inflammatory signalling pathways. The TLR4-MD2 receptor complex is crucial for the host recognition of Gram-negative bacterial infection, and pathogens have devised many strategies to evade or manipulate TLR4-MD2 activity. The TLR4-MD2 signalling pathway is therefore potentially an important therapeutic target. This Progress article focuses on recent exciting data that have revealed the structural basis of TLR4-MD2 recognition of LPS.

引用

页码：8 / 14

页数：7

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