Silvanus Thompson Memorial Lecture Molecular imaging using hyperpolarized 13C

被引:138
作者
Golman, K [1 ]
Olsson, LE
Axelsson, O
Månsson, S
Karlsson, M
Petersson, JS
机构
[1] Amersham Hlth R&D AB, SE-20512 Malmo, Sweden
[2] Malmo Univ Hosp, Dept Expt Res, SE-20502 Malmo, Sweden
关键词
D O I
10.1259/bjr/26631666
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
MRI provides unsurpassed soft tissue contrast, but the inherent low sensitivity of this modality has limited the clinical use to imaging of water protons. With hyperpolarization techniques, the signal from a given number of nuclear spins can be raised more than 100 000 times. The strong signal enhancement enables imaging of nuclei other than protons, e.g. C-13 and N-15, and their molecular distribution in vivo can be visualized in a clinically relevant time window. This article reviews different hyperpolarization techniques and some of the many application areas. As an example, experiments are presented where hyperpolarized C-13 nuclei have been injected into rabbits, followed by rapid C-13 MRI with high spatial resolution (scan time <1 s and 1.0 mm in-plane resolution). The high degree of polarization thus enabled mapping of the molecular distribution within various organs, a few seconds after injection. The hyperpolarized C-13 MRI technique allows a selective identification of the molecules that give rise to the MR signal, offering direct molecular imaging.
引用
收藏
页码:S118 / S127
页数:10
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