Use of myocardial electrical impedance to assess the efficacy of preconditioning

被引：1

作者：

del Río, CL ^{[1
]}

Dzwonczyk, R ^{[1
]}

Clymer, B ^{[1
]}

McSweeney, T ^{[1
]}

Awad, H ^{[1
]}

Czerwinski, P ^{[1
]}

Howie, MB ^{[1
]}

机构：

[1] Ohio State Univ, Columbus, OH 43210 USA

来源：

COMPUTERS IN CARDIOLOGY 2002, VOL 29 | 2002年 / 29卷

关键词：

D O I：

10.1109/CIC.2002.1166816

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Myocardial electrical impedance (MEI) has been found to correlate with ischemia and ischemic preconditioning (PC). In this study, the short-term effects of adenosine preconditioning on the MEI were studied in a swine model of beating heart coronary revascularization. Juvenile farm pigs were assigned to have either no PC (CTRL) or adenosine PC (ADO), receiving subsequently two ischemia/reperfusion (IR) insults. In both groups, MEI increased immediately with induced ischemia. However, its progression to ischemic plateau after reaching a maximum rate of change took significantly longer for ADO animals (7.13 +/- 11.03 min) than for the CTRL (4.56 +/- 0.16 min) (P<0.05). Such period of time was defined as a time constant. MEI was able to distinguish between study groups by evaluating the time required to reach ischemic plateau and from its rate of change (first derivate).

引用

页码：489 / 492

页数：4

共 11 条

[1] Changes in myocardial electrical impedance induced by coronary artery occlusion in pigs with and without preconditioning - Correlation with local ST-segment potential and ventricular arrhythmias [J].