How does an mRNA find its way? Intracellular localisation of transcripts

被引：26

作者：

Palacios, Isabel M. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2007年 / 18卷 / 02期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

RNA localisation; mechanisms; anchoring;

D O I：

10.1016/j.semcdb.2007.01.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The localisation of transcripts to specific regions of the cell probably occurs in all cell types and has many distinct functions that go from the control of body axis formation to learning and memory. mRNAs can be localised by a variety of mechanisms including local protection from degradation, diffusion to a localised anchor, and active transport by motor proteins along the cytoskeleton. In this review, I consider the evidence for each of these mechanisms using a limited, but illustrative, number of examples of localised mRNAs. (C) 2007 Published by Elsevier Ltd.

引用

页码：163 / 170

页数：8

共 62 条

[1] Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila [J].

Ashraf, SI ;

McLoon, AL ;

Sclarsic, SM ;

Kunes, S .

CELL, 2006, 124 (01) :191-205

[2]

Bergsten SE, 1999, DEVELOPMENT, V126, P659

[3] Kinesin II mediates Vg1 mRNA transport in Xenopus oocytes [J].

Betley, JN ;

Heinrich, B ;

Vernos, I ;

Sardet, C ;

Prodon, F ;

Deshler, JO .

CURRENT BIOLOGY, 2004, 14 (03) :219-224

[4] A function for kinesin I in the posterior transport of oskar mRNA and Staufen protein [J].

Brendza, RP ;

Serbus, LR ;

Duffy, JB ;

Saxton, WM .

SCIENCE, 2000, 289 (5487) :2120-2122

[5] Translocation of mRNAs by molecular motors: Think complex? [J].

Bullock, Simon L. .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2007, 18 (02) :194-201

[6] Guidance of bidirectional motor complexes by mRNA cargoes through control of dynein number and activity [J].

Bullock, Simon L. ;

Nicol, Alastair ;

Gross, Steven P. ;

Zicha, Daniel .

CURRENT BIOLOGY, 2006, 16 (14) :1447-1452

[7] Conserved signals and machinery for RNA transport in Drosophila oogenesis and embryogenesis [J].

Bullock, SL ;

Ish-Horowicz, D .

NATURE, 2001, 414 (6864) :611-616

[8] Production of gurken in the nurse cells is sufficient for axis determination in the Drosophila oocyte [J].

Cáceres, L ;

Nilson, LA .

DEVELOPMENT, 2005, 132 (10) :2345-2353

[9]

Carson JH, 2005, BIOL CELL, V97, P51

[10] In vivo analysis of Drosophila bicoid mRNA localization reveals a novel microtubule-dependent axis specification pathway [J].

Cha, BJ ;

Koppetsch, BS ;

Theurkauf, WE .

CELL, 2001, 106 (01) :35-46

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