A mathematical model for capillary network formation in the absence of endothelial cell proliferation

被引:69
作者
Anderson, ARA [1 ]
Chaplain, MAJ [1 ]
机构
[1] Univ Bath, Sch Math Sci, Bath BA2 7AY, Avon, England
基金
英国工程与自然科学研究理事会;
关键词
angiogenesis; endothelial cells; chemotaxis; haptotaxis;
D O I
10.1016/S0893-9659(98)00041-X
中图分类号
O29 [应用数学];
学科分类号
070104 ;
摘要
A mathematical model for endothelial cell migration during tumour-induced angiogenesis is presented. A possible explanation, in terms of desensitisation of cell-surface receptors, is given for the experimentally observed fact that without cell proliferation tumour vascularisation is never achieved.
引用
收藏
页码:109 / 114
页数:6
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