Antiviral Therapy for Hepatitis C Virus: Beyond the Standard of Care

被引：30

作者：

Delang, Leen ^{[1
]}

Coelmont, Lotte ^{[1
]}

Neyts, Johan ^{[1
]}

机构：

[1] KULeuven, Rega Inst Med Res, B-3000 Louvain, Belgium

来源：

VIRUSES-BASEL | 2010年 / 2卷 / 04期

关键词：

HCV; new antivirals; review; DEPENDENT RNA-POLYMERASE; PEGYLATED INTERFERON ALPHA-2A; SERINE-PROTEASE INHIBITORS; TREATMENT-NAIVE PATIENTS; IN-VITRO RESISTANCE; NONNUCLEOSIDE POLYMERASE; PEGINTERFERON ALPHA-2A; REPLICON VARIANTS; POTENT INHIBITORS; CROSS-RESISTANCE;

D O I：

10.3390/v2040826

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis C virus (HCV) represents a major health burden, with an estimated 180 million chronically infected individuals worldwide. These patients are at increased risk of developing liver cirrhosis and hepatocellular carcinoma. Infection with HCV is the leading cause of liver transplantation in the Western world. Currently, the standard of care (SoC) consists of pegylated interferon alpha (pegIFN-alpha) and ribavirin (RBV). However this therapy has a limited efficacy and is associated with serious side effects. Therefore more tolerable, highly potent inhibitors of HCV replication are urgently needed. Both Specifically Targeted Antiviral Therapy for HCV (STAT-C) and inhibitors that are believed to interfere with the host-viral interaction are discussed.

引用

页码：826 / 866

页数：41

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