Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression

被引：82

作者：

Anttila, S. ^{[1
]}

Huuhka, K.

Huuhka, M.

Rontu, R.

Hurme, M.

Leinonen, E.

Lehtima, T.

机构：

[1] Tampere Univ Hosp, Dept Psychiat, Pitkaniemi 33380, Finland

[2] Univ Tampere, Sch Med, FIN-33101 Tampere, Finland

[3] Tampere Univ Hosp, Ctr Lab Med, Dept Clin Chem, Lab Atherosclerosis Genet, Pitkaniemi 33380, Finland

[4] Univ Tampere, Sch Med, Dept Immunol & Microbiol, FIN-33101 Tampere, Finland

[5] Tampere Univ Hosp, Lab Ctr, Tampere, Finland

来源：

JOURNAL OF NEURAL TRANSMISSION | 2007年 / 114卷 / 08期

关键词：

5-HT1A; BDNF; polymorphism; major depression; treatment-resistant; electroconvulsive therapy;

D O I：

10.1007/s00702-007-0705-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Several studies have linked 5-HT1A C1019G and BDNF G196A (Val66Met) gene polymorphisms to major depressive disorder (MDD) and the actions of antidepressants. We attempt to show that the interaction between 5-HT1A and BDNF polymorphism predicts the risk of treatment-resistant depression. The sample consists of 119 patients with treatment-resistant MDD and 392 controls. 5-HT1A C1019G and BDNF G196A (Val66Met) polymorphisms were studied. The combination of 5-HT1A GG and BDNF GA + AA genotypes is associated with an increased risk of depression.

引用

页码：1065 / 1068

页数：4

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