Helicobacter pylori adheres selectively to Fusobacterium spp.

被引:47
作者
Andersen, RN
Ganeshkumar, N
Kolenbrander, PE
机构
[1] NIDR, Oral Infect & Immun Branch, NIH, Bethesda, MD 20892 USA
[2] Forsyth Dent Ctr, Boston, MA 02115 USA
来源
ORAL MICROBIOLOGY AND IMMUNOLOGY | 1998年 / 13卷 / 01期
关键词
Helicobacter-Fusobacterium coaggregation; helicobacter oral sequestration;
D O I
10.1111/j.1399-302X.1998.tb00751.x
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Helicobacter pylori strains ATCC 43504 and ATCC 43629 were tested for their ability to coaggregate with 79 strains of bacteria representing 16 genera. All except two of the strains were of human origin, and most of the strains were isolated from the oral cavity. The helicobacters failed to coaggregate with all strains except the fusobacteria. Several coaggregations were partially or completely inhibited by lactose. Strong coaggregation was seen with each of four subspecies of Fusobacterium nucleatum and with Fusobacterium periodonticum ATCC 33693, all of human dental plaque origin. In contrast, the helicobacters failed to coaggregate with non-plaque isolates, Fusobacterium mortiferum ATCC 25557 and Fusobacterium ulcerans ATCC 49185. Heat treatment of the fusobacteria inactivated their ability to coaggregate, whereas heating of the helicobacter partners had no effect, suggesting the presence of an adhesin on the fusobacteria and a corresponding receptor on the helicobacters. The potential ability of H. pylori to colonize the oral cavity by adhering selectively to the ubiquitous fusobacteria gives credence to the possibility that dental plaque may serve as a reservoir for this pathogen outside of the stomach.
引用
收藏
页码:51 / 54
页数:4
相关论文
共 42 条
[1]   HELICOBACTER-PYLORI IN DENTAL PLAQUE [J].
BANATVALA, N ;
LOPEZ, CR ;
OWEN, R ;
ABDI, Y ;
DAVIES, G ;
HARDIE, J ;
FELDMAN, R .
LANCET, 1993, 341 (8841) :380-380
[2]   ABSENCE OF HELICOBACTER-PYLORI IN DENTAL PLAQUES IN HELICOBACTER-PYLORI POSITIVE DYSPEPTIC PATIENTS [J].
BERNANDER, S ;
DALEN, J ;
GASTRIN, B ;
HEDENBORG, L ;
LAMKE, LO ;
OHRN, R .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1993, 12 (04) :282-285
[3]   EVALUATION OF THE POLYMERASE CHAIN-REACTION FOR DETECTING THE UREASE-C GENE OF HELICOBACTER-PYLORI IN GASTRIC BIOPSY SAMPLES AND DENTAL PLAQUE [J].
BICKLEY, J ;
OWEN, RJ ;
FRASER, AG ;
POUNDER, RE .
JOURNAL OF MEDICAL MICROBIOLOGY, 1993, 39 (05) :338-344
[4]  
CELESK RA, 1980, INFECT IMMUN, V29, P768
[5]   SPECIFICITY OF COAGGREGATION REACTIONS BETWEEN HUMAN ORAL STREPTOCOCCI AND STRAINS OF ACTINOMYCES-VISCOSUS OR ACTINOMYCES-NAESLUNDII [J].
CISAR, JO ;
KOLENBRANDER, PE ;
MCINTIRE, FC .
INFECTION AND IMMUNITY, 1979, 24 (03) :742-752
[6]   DENTAL PLAQUE - A PERMANENT RESERVOIR OF HELICOBACTER-PYLORI [J].
DESAI, HG ;
GILL, HH ;
SHANKARAN, K ;
MEHTA, PR ;
PRABHU, SR .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1991, 26 (11) :1205-1208
[7]   ISOLATION OF HELICOBACTER-PYLORI FROM SALIVA [J].
FERGUSON, DA ;
LI, CF ;
PATEL, NR ;
MAYBERRY, WR ;
CHI, DS ;
THOMAS, E .
JOURNAL OF CLINICAL MICROBIOLOGY, 1993, 31 (10) :2802-2804
[8]  
GANESHKUMAR N, 1989, 89 GEN M AM SOC MICR, P120
[9]   HELICOBACTER-PYLORI - ITS EPIDEMIOLOGY AND ITS ROLE IN DUODENAL-ULCER DISEASE [J].
GRAHAM, DY .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 1991, 6 (02) :105-113
[10]   HELICOBACTER-PYLORI, DUODENAL-ULCER, GASTRIC-CANCER - TUNNEL VISION OR BLINDERS [J].
GRAHAM, DY ;
GO, MF ;
GENTA, RM .
ANNALS OF MEDICINE, 1995, 27 (05) :589-594