Interfering with cancer: A brief outline of advances in RNA interference in oncology

被引：21

作者：

Rye, PD

Stigbrand, T

机构：

[1] Axis Shield ASA, NO-0581 Oslo, Norway

[2] Umea Univ, Dept Immunol, Umea, Sweden

来源：

TUMOR BIOLOGY | 2004年 / 25卷 / 5-6期

关键词：

molecular oncology; RNA interference;

D O I：

10.1159/000081403

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

RNA interference (RNAi) is a potent and ubiquitous gene-silencing mechanism that is generating considerable excitement in the fields of molecular biology and gene therapy. It is now in widespread use for loss-of-function analysis in many diseases including cancer. Nevertheless, RNAi is still in its infancy, with new discoveries appearing on a monthly basis. This article presents a brief outline of the history and recent advances in RNAi with a specific focus on its potential in oncology. Copyright (C) 2004 S. Karger AG. Basel.

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收藏

页码：329 / 336

页数：8

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