Viral versus cellular BCL-2 proteins

被引：49

作者：

Hardwick, JM

Bellows, DS

机构：

[1] Johns Hopkins Univ, Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA

来源：

CELL DEATH AND DIFFERENTIATION | 2003年 / 10卷 / Suppl 1期

关键词：

virus; BCL-2; BAX; BHRF1; Epstein-Barr virus (EBV); Kaposi's sarcoma-associated herpesvirus (KSHV); KSBcl-2; herpesvirus;

D O I：

10.1038/sj.cdd.4401133

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

All gamma herpesviruses and a few other viruses encode at least one homologue of the mammalian cell death inhibitor BCL-2. Gamma herpesviruses are associated with human and animal lymphoid and epithelial tumours. However, the role of these viral BCL-2 homologues in the virus replication cycle or in human disease is not known, though recent developments show progress in this area. The structure of viral BCL-2 family protein, KSBcl-2, is similar to that of cellular family members, but viral BCL-2 proteins differ functionally from the cellular proteins, apparently escaping the regulatory mechanisms to which their cellular counterparts are subjected. Thus, exploring the biochemical and biological functions of the viral BCL-2 family proteins will increase our understanding of their role in virus infections and will undoubtedly teach us something about their cellular kin.

引用

收藏

页码：S68 / S76

页数：9

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