Chain-branched acyclic phenethylthiocarbamates as vanilloid receptor antagonists

被引：18

作者：

Yoon, J

Choi, H

Lee, HJ

Ryu, CH

Park, HG

Suh, YG

Oh, U

Jeong, YS

Choi, JK

Park, YH

Kim, HD

机构：

[1] Sookmyung Womens Univ, Coll Pharm, Yongsan Ku, Seoul 140742, South Korea

[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[3] AmorePacific R & D Ctr, Youngin Si 449900, Kyounggi Do, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(03)00178-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of acyclic phenethylthiocarbamate derivatives have been synthesized, and their antagonist effect against vanilloid receptor tested. Chain branching led to a significant change in antagonist activity of the parent molecule. Ethyl-branched le showed a 6.3 muM Of IC50 value in Ca-45(2+)-influx assay. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：1549 / 1552

页数：4

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