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Cardiovascular risk factors and Alzheimer's disease:: a genetic association study in a population aged 85 or over

被引：44
作者：
Myllykangas, L
Polvikoski, T
Sulkava, R
Verkkoniemi, A
Tienari, P
Niinistö, L
Kontula, K
Hardy, J
Haltia, M
Pérez-Tur, J
机构：
[1] Mayo Clin Jacksonville, Neurogenet Lab, Jacksonville, FL 32224 USA
[2] Univ Helsinki, Dept Pathol, FIN-00014 Helsinki, Finland
[3] Univ Helsinki, Cent Hosp, FIN-00014 Helsinki, Finland
[4] Univ Kuopio, Dept Publ Hlth & Gen Practice, Div Geriatr, FIN-70211 Kuopio, Finland
[5] Univ Helsinki, Dept Neurol, FIN-00290 Helsinki, Finland
[6] Katriina Geriatr Hosp, FIN-01760 Vantaa, Finland
[7] Univ Helsinki, Dept Med, FIN-00290 Helsinki, Finland
[8] CSIC, Inst Biomed Valencia, Unitat Genet Mol, E-46010 Valencia, Spain
来源：
NEUROSCIENCE LETTERS | 2000年 / 292卷 / 03期
基金：
芬兰科学院;
关键词：
Alzheimer's disease; genetic association; very old; genetic risk factors; autopsy; cardiovascular risk factors;
D O I：
10.1016/S0304-3940(00)01467-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Increasing evidence suggests a relation between vascular disorders and late-onset Alzheimer's disease (AD). We performed an association analysis of low-density lipoprotein receptor-related protein (LRP), lipoprotein lipase (LPL), and angiotensin converting enzyme (ACE) genes, known to be involved in vascular disorders, and AD. Genotyping was carried out in 113 patients with clinically defined Alzheimer's disease (NINCDS-ADRDA criteria) and 203 non-demented controls in a prospective, population-based study of people aged 85 years or over (Vantaa 85+ Study). Corresponding analysis was performed on 121 neuropathologically verified AD patients (CERAD criteria) and 75 controls derived from the same study population. We did not find significant associations between the polymorphisms studied and AD. However, analysis of the LPL polymorphism showed a weak trend (uncorrected P-value 0.095) towards protection against neuropathologically defined AD. Our study is based on very elderly Finns. Therefore, further studies are warranted in other populations. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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页码：195 / 198
页数：4
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