Synthesis and antitumor activity of cyclopentadienyltitanium substituted polyoxotungstate [CoW11O39(CpTi)]7- (CP=η5-C5H5)

被引：94

作者：

Wang, XH

Liu, JF ^{[1
]}

Li, JX

Yang, Y

Liu, JT

Bin, L

Pope, MT

机构：

[1] NE Normal Univ, Dept Chem, Changchun 130024, Peoples R China

[2] Georgetown Univ, Dept Chem, Washington, DC 20057 USA

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2003年 / 94卷 / 03期

基金：

中国国家自然科学基金;

关键词：

polyoxometalates; polyoxotungstate; antitumor activity; cancer cells;

D O I：

10.1016/S0162-0134(02)00631-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel polyoxotungstate [CoW11O39(CpTi)](7-) (Cp=eta(5)-C5H5) has been prepared. This complex exhibits the highest antitumor activity in vitro among the cyclopentadienyltitanium substituted polyoxometalates investigated and has a remarkable inhibitory action on three types of human cancer cells, SSMC-7721, HL-60 and HLC, in vivo. (C) 2002 Published by Elsevier Science Inc.

引用

页码：279 / 284

页数：6

共 9 条

[1] Main-group element, organic, and organometallic derivatives of polyoxometalates [J].