Human papillomavirus and circumcision: A meta-analysis

被引:40
作者
Van Howe, Robert S. [1 ]
机构
[1] Michigan State Univ, Coll Human Med, Dept Pediat, Marquette, MI 49855 USA
关键词
circumcision; human papillomavirus; penile cancer; meta-analysis;
D O I
10.1016/j.jinf.2006.08.005
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: Determine the relationship of circumcision status to the risk for genital infection with human papillomavirus (HPV). Methods: A MEDLINE search and a review of references in published articles were used to identify publications from peer-reviewed journals in Index Medicus with data on circumcision status in patients with and without HPV infections. Inclusion criteria included diagnosis by culture, biopsy, or PCR, determination of circumcision status by physical examination, and multiple site sampling including the shaft of the penis. A meta-analysis was performed with sensitivity analyses. Results: Sixteen articles contained data on circumcision status in patients with and without HPV infections. Eight studies used accurate diagnostic methods. Only three articles satisfied the strict inclusion criteria. There was no significant association between circumcision status and HPV infection (random-effects model summary effect OR = 1.20, 95% CI = 0.80-1.79) in these three studies. If the eight studies using accurate diagnostic methods are adjusted for the method of determining circumcision status and failure to sample the penile shaft using meta-regression the summary effects odds ratio is 1.25 (95%Cl = 0.95-1.67). Conclusions: The medical literature does not support the claim that circumcision reduces the risk for genital HPV infection. To correctly assess the risk of HPV infection in circumcised mates, the penile shaft needs to be sampled for HPV infection. (c) 2006 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:490 / 496
页数:7
相关论文
共 45 条
  • [1] [Anonymous], 2000, METAANALYSIS DECISIO
  • [2] AYNAUD O, 1994, CANCER, V74, P1762, DOI 10.1002/1097-0142(19940915)74:6<1762::AID-CNCR2820740619>3.0.CO
  • [3] 2-1
  • [4] Aynaud O, 1999, BJU INT, V84, P57
  • [5] Condom use and other factors affecting penile human papillomavirus detection in men attending a sexually transmitted disease clinic
    Baldwin, SB
    Wallace, DR
    Papenfuss, MR
    Abrahamsen, M
    Vaught, LC
    Giuliano, AR
    [J]. SEXUALLY TRANSMITTED DISEASES, 2004, 31 (10) : 601 - 607
  • [6] OPERATING CHARACTERISTICS OF A BANK CORRELATION TEST FOR PUBLICATION BIAS
    BEGG, CB
    MAZUMDAR, M
    [J]. BIOMETRICS, 1994, 50 (04) : 1088 - 1101
  • [7] THE MALE FACTOR IN THE ETIOLOGY OF CERVICAL-CANCER AMONG SEXUALLY MONOGAMOUS WOMEN
    BRINTON, LA
    REEVES, WC
    BRENES, MM
    HERRERO, R
    GAITAN, E
    TENORIO, F
    DEBRITTON, RC
    GARCIA, M
    RAWLS, WE
    [J]. INTERNATIONAL JOURNAL OF CANCER, 1989, 44 (02) : 199 - 203
  • [8] Male circumcision, penile human papillomavirus infection, and cervical cancer in female partners.
    Castellsague, X
    Bosch, FX
    Munoz, N
    Meijer, CJLM
    Shah, KV
    de Sanjose, S
    Eluf-Neto, J
    Ngelangel, CA
    Chichareon, S
    Smith, JS
    Herrero, R
    Moreno, V
    Franceschi, S
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (15) : 1105 - 1112
  • [9] CIRCUMCISION AND SEXUALLY-TRANSMITTED DISEASES
    COOK, LS
    KOUTSKY, LA
    HOLMES, KK
    [J]. AMERICAN JOURNAL OF PUBLIC HEALTH, 1994, 84 (02) : 197 - 201
  • [10] Pseudo hyperplastic squamous cell carcinoma of the penis associated with lichen sclerosus. An extremely well-differentiated, nonverruciform neoplasm that preferentially affects the foreskin and is frequently misdiagnosed - A report of 10 cases of a distinctive clinicopathologic entity
    Cubilla, AL
    Velazquez, EF
    Young, RH
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2004, 28 (07) : 895 - 900