Variations in plasma soluble tumour necrosis factor receptors after diet-induced weight loss in obesity

被引：48

作者：

Bastard, JP

Jardel, C

Bruckert, E

Vidal, H

Hainque, B

机构：

[1] Hop La Pitie Salpetriere, AP HP, Serv Biochim, Paris, France

[2] Hop Tenon, AP HP, Serv Biochim, F-75970 Paris, France

[3] Univ Paris 06, INSERM, U402, F-75012 Paris, France

[4] Hop Pitie, AP HP, Serv Endocrinol, F-75651 Paris, France

[5] Fac Med RTH Laennec, INSERM, U449, Lyon, France

[6] Univ Paris 05, UFR Pharm, Dept Biochim, Paris, France

来源：

DIABETES OBESITY & METABOLISM | 2000年 / 2卷 / 05期

关键词：

very low calorie diet (VLCD); weight loss; insulin resistance; obesity; tumour necrosis factor-alpha; soluble receptors;

D O I：

10.1046/j.1463-1326.2000.00090.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this study was to investigate the variations in the plasma levels of the soluble tumour necrosis factor receptor type-I (sTNFR-I) and type-II (sTNFR-II) during weight loss which was induced by 3 weeks on a very low calorie diet (3.9 +/- 0.1 MJ/day), in 17 non-diabetic obese women. Plasma sTNFR-I concentrations decreased significantly after weight loss (p < 0.05), but there was no significant change in plasma sTNFR-II. As the diet was associated with a significant decrease in body fat mass (approximate to 2.5 kg), this result supports the emerging concept that adipose tissue can produce significant amounts of sTNFR-I and that this production can be modified by weight loss in human obesity.

引用

页码：323 / 325

页数：3

共 12 条

[1]

Bastard JP, 1997, DIABETES METAB, V23, P87

[2] Increased adipose tissue PC-1 protein content, but not tumour necrosis factor-alpha gene expression, is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine-kinase activity [J].