Lipid droplets in inflammation and cancer

被引：332

作者：

Bozza, Patricia T. ^{[1
]}

Viola, Joao P. B. ^{[2
]}

机构：

[1] Fundacao Oswaldo Cruz, Lab Imunofarmacol, Inst Oswaldo Cruz, BR-21045900 Rio De Janeiro, Brazil

[2] Natl Canc Inst, Div Cellular Biol, Rio De Janeiro, Brazil

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2010年 / 82卷 / 4-6期

关键词：

Lipid droplet; Lipid bodies; Inflammation; Cancer; Eicosanoids; Lipid metabolism; PROLIFERATOR-ACTIVATED RECEPTOR; DIFFERENTIATION-RELATED PROTEIN; LOW-DENSITY-LIPOPROTEIN; FOAM CELL-FORMATION; ENDOPEROXIDE SYNTHASE CYCLOOXYGENASE; HEPATITIS-C VIRUS; MACROPHAGE-GENE-EXPRESSION; DOMINANT-NEGATIVE MUTANT; UNSATURATED FATTY-ACIDS; HUMAN FETAL MEMBRANES;

D O I：

10.1016/j.plefa.2010.02.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Accumulation of lipid droplets (also known as lipid bodies or adiposomes) within leukocytes, epithelial cells, hepatocytes and other non-adipocytic cells is a frequently observed phenotype in infectious, neoplastic and other inflammatory conditions. Lipid droplet biogenesis is a regulated cellular process that culminates in the compartmentalization of lipids and of an array of enzymes, protein kinases and other proteins, suggesting that lipid droplets are inducible organelles with roles in cell signaling, regulation of lipid metabolism, membrane trafficking and control of the synthesis and secretion of inflammatory mediators. Enzymes involved in eicosanoid synthesis are localized at lipid droplets and lipid droplets are sites for eicosanoid generation in cells during inflammation and cancer. In this review, we discuss the current evidence related to the biogenesis and function of lipid droplets in cell metabolism and signaling in inflammation and cancer. Moreover, the potential of lipid droplets as markers of disease and targets for novel anti-inflammatory and antineoplastic therapies will be discussed. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：243 / 250

页数：8

共 113 条

[1] Lipid bodies are reservoirs of cyclooxygenase-2 and sites of prostaglandin-E2 synthesis in colon cancer cells [J].

Accioly, Maria T. ;

Pacheco, Patricia ;

Maya-Monteiro, Clarissa M. ;

Carrossini, Nina ;

Robbs, Bruno K. ;

Oliveira, Silvia S. ;

Kaufmann, Cristiane ;

Morgado-Diaz, Jose A. ;

Bozza, Patricia T. ;

Viola, Joao P. B. .

CANCER RESEARCH, 2008, 68 (06) :1732-1740

[2] Mycobacterium bovis Bacillus Calmette-Guerin Infection Induces TLR2-Dependent Peroxisome Proliferator-Activated Receptor γ Expression and Activation: Functions in Inflammation, Lipid Metabolism, and Pathogenesis [J].

Almeida, Patricia E. ;

Silva, Adriana R. ;

Maya-Monteiro, Clarissa M. ;

Torocsik, Daniel ;

D'Avila, Heloisa ;

Dezsoe, Balazs ;

Magalhaes, Kelly G. ;

Castro-Faria-Neto, Hugo C. ;

Nagy, Laszlo ;

Bozza, Patricia T. .

JOURNAL OF IMMUNOLOGY, 2009, 183 (02) :1337-1345

[3] Electron microscope immunocytochemical localization of cyclooxygenase-1 and-2 in pseudopregnant rat corpus luteum during luteolysis [J].

Arend, A ;

Masso, R ;

Masso, M ;

Selstam, G .

PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2004, 74 (1-4) :1-10

[4] The cellular biology of eosinophil eicosanoid formation and function [J].

Bandeira-Melo, C ;

Bozza, PT ;

Weller, PF .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2002, 109 (03) :393-400

[5] IL-16 promotes leukotriene C4 and IL-4 release from human eosinophils via CD4-and autocrine CCR3-chemokine-mediated signaling [J].

Bandeira-Melo, C ;

Sugiyama, K ;

Woods, LJ ;

Phoofolo, M ;

Center, DM ;

Cruikshank, WW ;

Weller, PF .

JOURNAL OF IMMUNOLOGY, 2002, 168 (09) :4756-4763

[6] Extranuclear lipid bodies, elicited by CCR3-mediated signaling pathways, are the sites of chemokine-enhanced leukotriene C4 production in eosinophils and basophils [J].

Bandeira-Melo, C ;

Phoofolo, M ;

Weller, PF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (25) :22779-22787

[7]

Bartemes KR, 1999, J IMMUNOL, V162, P2982

[8] Cytosolic lipid droplets increase in size by microtubule-dependent complex formation [J].

Boström, P ;

Rutberg, M ;

Ericsson, J ;

Holmdahl, P ;

Andersson, L ;

Frohman, MA ;

Borén, J ;

Olofsson, SO .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (09) :1945-1951

[9] Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus [J].

Boulant, Steeve ;

Targett-Adams, Paul ;

McLauchlan, John .

JOURNAL OF GENERAL VIROLOGY, 2007, 88 :2204-2213

[10] Phosphocholine as a pattern recognition ligand for CD36 [J].

Boullier, A ;

Friedman, P ;

Harkewicz, R ;

Hartvigsen, K ;

Green, SR ;

Almazan, F ;

Dennis, EA ;

Steinberg, D ;

Witztum, JL ;

Quehenberger, O .

JOURNAL OF LIPID RESEARCH, 2005, 46 (05) :969-976

← 1 2 3 4 5 6 7 8 9 10 →