Use of 1,2,3-trisubstituted cyclopropanes as conformationally constrained peptide mimics in SH2 antagonists

被引：22

作者：

Davidson, JP

Martin, SF ^{[1
]}

机构：

[1] Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA

[2] Univ Texas, Inst Cellular & Mol Biol, Austin, TX 78712 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 49期

基金：

美国国家卫生研究院;

关键词：

peptide mimics; cyclopropane; asymmetric synthesis;

D O I：

10.1016/S0040-4039(00)01611-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel conformationally constrained phosphotyrosine pseudopeptide derivatives of the tetrapeptide pY-E-E-I were prepared and evaluated as SH2 binding antagonists. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：9459 / 9464

页数：6

共 39 条

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