Arrest of CFTRΔF508 folding

被引：21

作者：

Cyr, DM ^{[1
]}

机构：

[1] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, N Carolina Cyst Fibrosis Res Ctr, Chapel Hill, NC 27599 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2005年 / 12卷 / 01期

关键词：

D O I：

10.1038/nsmb0105-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The deletion of residue 508 in CFTR is the most common cystic fibrosis-causing mutation. Recent studies indicate that the main chain and side chain of this residue contribute to the proper folding of CFTR at different stages.

引用

页码：2 / 3

页数：2

共 18 条

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