Arrest of CFTRΔF508 folding

被引:21
作者
Cyr, DM [1 ]
机构
[1] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, N Carolina Cyst Fibrosis Res Ctr, Chapel Hill, NC 27599 USA
关键词
D O I
10.1038/nsmb0105-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The deletion of residue 508 in CFTR is the most common cystic fibrosis-causing mutation. Recent studies indicate that the main chain and side chain of this residue contribute to the proper folding of CFTR at different stages.
引用
收藏
页码:2 / 3
页数:2
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